Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Domperidone. If you are concerned about side effects, discuss the risks and benefits of Domperidone with your doctor.

The following side effects have been reported by at least 1% of people taking Domperidone. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• abdominal cramps
• breast pain
• Diarrhea
• Dry Mouth
• headache
• migraine
• nausea
• rash

Although most of these side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• breast milk flowing from the nipple
• fast, pounding, or racing heartbeat or pulse
• menstrual irregularities
• swelling of the breast (males)

Stop taking the medication and seek immediate medical attention if any of the following occur:

• dizziness or fainting
• irregular heartbeat
• signs of an allergic reaction (such as difficulty breathing, Hives, swelling of the face or throat)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Domperidone.

Each white, plain-coated, round, biconvex tablet, engraved with "rph D51" on one side and plain on the other, contains 12.72 mg of domperidone maleate (equivalent to 10 mg of domperidone). Nonmedicinal ingredients: cornstarch, croscarmelose sodium, hydroxypropyl methylcellulose, lactose, magnesium stearate, microcrystalline cellulose, polydextrose, polyethylene glycol, povidone, sodium docusate 85%-sodium benzoate 15%, titanium dioxide, and triacetin.

Do not take domperidone if you:

• are allergic to domperidone or any ingredients of the medication
• are taking the medications in the same families as ketoconazole, erythromycin, ritonavir, or nefazodone
• are taking medications which cause QT prolongation
• have bleeding in the stomach or intestines
• have a blockage in the stomach or intestines
• have breaks in the lining of the stomach or intestines
• have a prolactinoma (a tumour of the pituitary gland)
• have uncorrected levels of potassium, magnesium, or calcium in your blood
• have cardiac disease (e.g., heart failure)
• have QT prolongation (a type of irregular heartbeat)
• have moderate or severe liver impairment

There may be an interaction between domperidone and any of the following:

• Alfuzosin
• amantadine
• Amiodarone
• anticholinergics (e.g., Benztropine, , oxybutinin)
• antihistamines (e.g., cetirizine, doxylamine, Diphenhydramine, Hydroxyzine, Loratadine)
• antipsychotic medications (e.g., Haloperidol, Risperidone, Quetiapine)
• Apomorphine
• Aprepitant
• "azole" antifungals (e.g., fluconazole, itraconazole, ketoconazole, Voriconazole)
• Buprenorphine
• Buserelin
• Capecitabine
• calcium channel blockers (e.g., Amlodipine, Diltiazem, Nifedipine, Verapamil)
• Ceritinib
• chloral hydrate
• chloroquine
• Cobicistat
• conivaptan
• Crizotinib
• Cyclosporine
• Degarelix
• Disopyramide
• Donepezil
• Doxepin
• Dronedarone
• Famotidine
• Fingolimod
• Flecainide
• formoterol
• Galantamine
• grapefruit juice
• HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs; e.g., delavirdine, efavirenz, etravirine, nevirapine)
• HIV protease inhibitors (e.g., indinavir, atazanavir, lopinavir, nelfinavir, ritonavir)
• hydroxychloroquine
• Indacaterol
• Indapamide
• Ivabradine
• lithium
• Lomitapide
• Loperamide
• macrolide antibiotics (e.g., azithromycin, clarithromycin, erythromycin)
• Maprotiline
• mefloquine
• Methadone
• Metoclopramide
• Metronidazole
• mifepristone
• Mirabegron
• Mirtazapine
• monoamine oxidase inhibitors (M.O.S. e.g., Moclobemide, Phenelzine, Rasagiline, Selegiline, Tranylcypromine, nefazodone)
• Octreotide
• olodaterol
• pentamidine
• Primaquine
• probucol
• procainamide
• Propafenone
• protein kinase inhibitors (e.g., Bosutinib, Dasatinib, Erlotinib, imatinib, Nilotinib)
• Romidepsin
• quinidine
• quinine
• quinolone antibiotics (e.g., ciprofloxacin, moxifloxacin, Norfloxacin, levofloxacin)
• salmeterol
• selective serotonin reuptake inhibitors (SSRIS; e.g., Citalopram, Fluoxetine, Paroxetine, Sertraline)
• serotonin antagonists (anti-emetic medications; e.g., Granisetron, ondansetron)
• simeprevir
• Solifenacin
• sotalol
• Stiripentol
• sulfamethoxazole
• tacrolimus
• Tamoxifen
• Tetrabenazine
• Trazodone
• tricyclic antidepressants (e.g., Amitriptyline, Nortriptyline)
• Trimethoprim
• Vardenafil
• Venlafaxine
• vilanterol
• Vorinostat

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Domperidone. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin taking a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Domperidone.

Heart rhythm problems and cardiac arrest: Recent studies have shown that the risk of serious abnormal heart rhythms or cardiac arrest (sudden death) may be higher in people who take more than 30 mg of domperidone per day, or in people who are over 60 years of age. If you have a heart condition with abnormal electrical activity of your heart (e.g., QT prolongation), heart failure, or low blood levels of magnesium or potassium, discuss with your doctor how Domperidone may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Domperidone, and whether any special monitoring is needed.

This is especially important if you are taking other medications that can change the electrical activity of the heart or increase the amount of domperidone in your blood. Certain medications (e.g., Sotalol, quinidine, thioridazine, Chlorpromazine, Pimozide, moxifloxacin, Mefloquine, pentamidine, arsenic trioxide, Ondansetron, probucol, Tacrolimus) can increase the risk of a type of abnormal heart rhythm called QT prolongation, and should not be used in combination with domperidone if possible. You are more at risk for this type of abnormal heart rhythm and its complications if you:

• are female
• are older than 65 years of age
• have a family history of sudden cardiac death
• have a history of heart disease or abnormal heart rhythms
• have a slow heart rate
• have congenital prolongation of the QT interval
• have diabetes
• have had a Stroke
• have low potassium, magnesium, or calcium levels
• have nutritional deficiencies

Hormone levels: Domperidone may increase prolactin, a hormone in the body. If you have a history of Breast Cancer, ask your doctor about the benefits and risks associated with using Domperidone, since some breast cancers are thought to be prolactin-dependent.

Kidney function: Reduced kidney function may cause Domperidone to build up in the body, causing side effects. If you have reduced kidney function, discuss with your doctor how Domperidone may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Domperidone, and whether any special monitoring is needed. Your doctor may suggest a lower dose or that you take Domperidone only once or twice a day.

Liver function: Liver disease or reduced liver function may cause Domperidone to build up in the body, causing side effects. If you have liver problems, discuss with your doctor how Domperidone may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Domperidone, and whether any special monitoring is needed.

Pregnancy: Domperidone should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Domperidone, contact your doctor immediately.

Breast-feeding: Domperidone passes into breast milk. If you are a breast-feeding mother and are taking domperidone, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using Domperidone have not been established for children.

Seniors: People over the age of 60 appear to be more likely to experience heart problems including Heart Attack with the use of domperidone. Talk to your doctor about the risks and benefits of taking Domperidone.

Domperidone belongs to the group of medications called dopamine antagonists. It is used to treat slowed movement in the gastrointestinal tract associated with Diabetes and gastritis (inflammation of the stomach lining). For these people, domperidone improves symptoms of nausea, vomiting, bloating, and feeling of fullness.

Domperidone is also used to prevent stomach problems such as nausea and vomiting associated with certain medications used to treat Parkinson's Disease. It works to improve symptoms by helping the stomach to empty more quickly and to reduce nausea.

Domperidone may be available under multiple brand names and/or in several different forms. Any specific brand name of Domperidone may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Domperidone may not be used for all of the conditions discussed here.

Your doctor may have suggested Domperidone for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking Domperidone, speak to your doctor. Do not stop taking Domperidone without consulting your doctor.

Do not give Domperidone to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take Domperidone if their doctor has not prescribed it.