Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Suprefact Depot (Buserelin).

Anemia: Reduced testosterone levels contribute to low levels of red blood cells. If you experience symptoms of reduced red blood cell count (anemia) such as shortness of breath, pale skin, or feeling unusually tired, contact your doctor as soon as possible.

Your doctor will do blood tests regularly to monitor the number of specific types of blood cells, including red blood cells, in your blood.

Blood pressure: If you have high blood pressure, Suprefact Depot (Buserelin) may increase your blood pressure. Your blood pressure should be checked regularly while using Suprefact Depot (Buserelin).

Depression: Changed levels of hormones in the body have been known to cause mood swings and symptoms of depression. If you have depression or a history of depression, discuss with your doctor how Suprefact Depot (Buserelin) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Suprefact Depot (Buserelin), and whether any special monitoring is needed.

If you experience symptoms of depression such as poor concentration, changes in weight, changes in sleep, or decreased interest in activities, or notice them in a family member who is taking Suprefact Depot (Buserelin), contact your doctor as soon as possible.

Diabetes: Suprefact Depot (Buserelin) may cause a loss of blood glucose control, and glucose tolerance may change. People with diabetes may find it necessary to monitor their blood sugar more frequently while using Suprefact Depot (Buserelin).

If you have diabetes or are at risk for developing diabetes, discuss with your doctor how Suprefact Depot (Buserelin) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Suprefact Depot (Buserelin), and whether any special monitoring is needed.

Disease symptoms: Sometimes when Suprefact Depot (Buserelin) is started, you may experience a temporary worsening of your symptoms that will last usually less than 10 days. If you have prostate cancer, you may also experience new symptoms such as bone pain, tingling or numbness, or blood in the urine, and your doctor may prescribe a medication to help prevent this. If you experience worsening of your symptoms or any new symptoms, contact your doctor.

Dizziness: Suprefact Depot (Buserelin) can cause dizziness. Do not drive or operate machinery until you know Suprefact Depot (Buserelin) does not affect your ability to perform these tasks safely.

Heart problems: Suprefact Depot (Buserelin) may increase the risk of heart problems such as changes in heart rhythm. You may be more at risk of experiencing heart problems if you have congenital long QT syndrome, electrolyte (e.g., potassium) abnormalities, or Congestive Heart Failure, or you are taking medications that affect heart rhythm (e.g., quinidine, procainamide, Amiodarone, Sotalol, Flecainide). Discuss with your doctor how Suprefact Depot (Buserelin) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Suprefact Depot (Buserelin), and whether any special monitoring is needed.

Men and the heart: There may be an increased risk of heart-related events (e.g., heart attacks, Stroke, heart-related death) in men being treated for prostate cancer with GnRH medications.

Before you start treatment, tell your doctor if you have diabetes or heart disease, have had a previous Heart Attack or stroke, or have cardiovascular risk factors (e.g., high blood pressure, smoking, or cholesterol). If you have any of these conditions, discuss with your doctor how Suprefact Depot (Buserelin) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Suprefact Depot (Buserelin), and whether any special monitoring is needed.

Osteoporosis: Suprefact Depot (Buserelin) can decrease bone density that can lead to osteoporosis and bone factures. Your doctor will monitor you for this while you are using Suprefact Depot (Buserelin). If you have osteoporosis or are at risk for it (e.g., have been smoking or drinking excessive amounts of alcohol for a long time, have a family history of osteoporosis, or are taking medications such as Prednisone or anti-seizure medications), discuss with your doctor how Suprefact Depot (Buserelin) may affect your medical condition and whether any special monitoring is needed.

Pregnancy: Suprefact Depot (Buserelin) should not be used by pregnant women. Use an effective nonhormonal method of birth control (e.g., condom, diaphragm, IUD) while you are using Suprefact Depot (Buserelin). If you become pregnant while using Suprefact Depot (Buserelin), stop using the medication and contact your doctor immediately.

Breast-feeding: Suprefact Depot (Buserelin) passes into breast milk. If you are a breast-feeding mother and are taking Suprefact Depot (Buserelin), it may affect your baby. Women should not breast-feed while using Suprefact Depot (Buserelin).

Children: The safety and effectiveness of using Suprefact Depot (Buserelin) have not been established for children and adolescents less than 18 years of age.