Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Agrylin (Anagrelide). If you are concerned about side effects, discuss the risks and benefits of Agrylin (Anagrelide) with your doctor.

The following side effects have been reported by at least 1% of people taking Agrylin (Anagrelide). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• back pain
• chills
• Constipation
• decreased appetite
• Diarrhea
• difficulty sleeping
• dizziness when rising from a sitting or lying position
• eye irritation or infection
• fatigue
• flu-like symptoms (e.g., cough, headache, sore throat)
• flushing
• gas and bloating
• general feeling of being unwell
• headache
• muscle aches and pains
• nausea
• ringing in the ears
• skin irritation (redness and itchiness)
• spinning, whirling sensation
• stomach pain
• sweating
• tingling sensations or numbness
• weight changes
• vomiting

Although most of these side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• confusion
• decreased sense of touch
• dehydration
• Fever
• increased blood pressure
• memory loss
• pounding or irregular heartbeat
• signs and symptoms of bleeding (e.g., easy bruising, nosebleeds, blood in urine or stools, bleeding gums, cuts that don't stop bleeding)
• signs and symptoms of breathing problems (e.g., shortness of breath, troubled breathing, wheezing, or tightness in chest, fast or irregular breathing)
• signs and symptoms of heart problems (e.g., fast, irregular heartbeat or pulse, chest pain, difficulty breathing, swelling in the ankles and legs)
• signs and symptoms of Depression (e.g., poor concentration, changes in weight, changes in sleep, decreased interest in activities, thoughts of suicide)
• signs of kidney problems (e.g., increased urination at night, decreased urine production, blood in the urine)
• signs and symptoms of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
• signs and symptoms of Bronchitis or pneumonia (e.g., fever, cough, shortness of breath)
• symptoms of irregular heartbeat (e.g., chest pain, dizziness, rapid, pounding heartbeat, shortness of breath)
• trouble swallowing
• vision changes

Stop taking the medication and seek immediate medical attention if any of the following occur:

• chest pain
• fainting/loss of consciousness
• dizziness or fainting with irregular heart rhythm
• signs of a blood clot in the arm or leg (tenderness, pain, swelling, warmth, or redness in the arm or leg) or lungs (difficulty breathing, sharp chest pain that is worse when breathing in, coughing, coughing up blood, sweating, or passing out)
• signs of stroke (e.g., sudden or severe headache; sudden loss of coordination; vision changes; sudden slurring of speech; or unexplained weakness, numbness, or pain in arm or leg)
• trouble breathing or shortness of breath

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Agrylin (Anagrelide).