Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Dipyridamole. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking Dipyridamole. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• abdominal or stomach cramps
• Diarrhea
• dizziness or lightheadedness
• flushing
• headache
• nausea or vomiting
• weakness

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• chest pain
• gallstones
• increased heart rate
• Low Blood Pressure (symptoms may include dizziness or fainting)

• signs of clotting problems (e.g., unusual nosebleeds, bruising, blood in urine, coughing blood, bleeding gums, cuts that don’t stop bleeding)
• signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
• skin rash

Stop taking the medication and seek immediate medical attention if any of the following occur:

• chest pain
• signs of bleeding in the stomach (e.g., bloody, black, or tarry stools, spitting up of blood, vomiting blood or material that looks like coffee grounds)
• symptoms of a serious allergic reaction (such as Hives, difficulty breathing, or swelling of the face or throat)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Dipyridamole.

Intravenous solution: Each mL contains 5 mg of dipyridamole. Nonmedicinal ingredients:  tartaric acid, polyethylene glycol 600, hydrochloric acid, and water for injection.

Do not take dipyridamole if you are allergic to dipyridamole or any ingredients of the medication.

Do not give the injectable form of Dipyridamole to anyone who is in a state of shock or collapse.

There may be an interaction between dipyridamole and any of the following:

• acetylsalicylic acid (ASA)
• Aliskiren
• alpha blockers (e.g., Alfuzosin, Doxazosin, Tamsulosin)
• alpha agonists (e.g., Clonidine, methyldopa)
• Amiodarone
• anti-cancer medications (e.g., Doxorubicin, Etoposide, Topotecan, Vinblastine)
• Apixaban
• beta-adrenergic blockers (e.g., Atenolol, Propranolol, Sotalol)
• calcium channel blockers (e.g., Amlodipine, Diltiazem, Nifedipine, Verapamil)
• Carvedilol
• cetirizine
• ciprofloxacin (systemic)
• cholinesterase inhibitors (e.g., Donepezil, Galantamine, Rivastigmine)
• Clopidogrel
• Colchicine
• Cyclosporine
• dabigatran
• Dexamethasone
• Digoxin
• erythromycin
• estrogens (e.g., conjugated estrogen, Estradiol, ethinyl estradiol)
• “gliptin” Diabetes medications (e.g., Linagliptin, Saxagliptin, Sitagliptin)
• glucosamine
• Heparin
• herbal products that affect blood clotting (e.g., cat's claw, chamomile, fenugreek, evening primrose, feverfew, garlic, ginger, ginseng, turmeric)
• HIV protease inhibitors (e.g., atazanavir, indinavir, ritonavir, saquinavir)
• Hydrocortisone
• Loperamide
• low molecular weight heparins (e.g., Dalteparin, Enoxaparin, Tinzaparin)
• Methotrexate
• multivitamin supplements
• non-steroidal anti-inflammatory medications (NSAIDs; e.g., Diclofenac, Ibuprofen, Naproxen)
• Ondansetron
• omega-3 fatty acids
• Paliperidone
• Pentoxifylline
• protein kinase inhibitors (e.g., Crizotinib, Dasatinib, imatinib, Nilotinib)
• Prucalopride
• quinidine
• quinine
• Ranitidine
• rifampin
• Risperidone
• Rivaroxaban
• Romidepsin
• selective serotonin reuptake inhibitors (SSRIs; e.g., Citalopram, Fluoxetine, Paroxetine, Sertraline)
• serotonin-norepinephrine reuptake inhibitors (SNRIs; Desvenlafaxine, Duloxetine, Venlafaxine)
• "statin" anti-cholesterol medications (e.g., Atorvastatin, Lovastatin, Simvastatin)
• Tacrolimus
• theophyllines (with injectable form of dipyridamole; Aminophylline, Theophylline)
• Ticagrelor
• Ticlopidine
• Tolvaptan
• vitamin E
• Warfarin

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Dipyridamole. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Dipyridamole.

Liver function: Liver disease or reduced liver function may cause Dipyridamole to build up in the body, causing side effects. If you have liver problems, discuss with your doctor how Dipyridamole may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Dipyridamole, and whether any special monitoring is needed. Your doctor may want to test your liver function regularly with blood tests while you are taking Dipyridamole.

If you experience symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin, contact your doctor immediately.

Low blood pressure: Dipyridamole may cause lowering of blood pressure and increase the effect of blood pressure-lowering medications.

Pregnancy: Dipyridamole should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Dipyridamole, contact your doctor immediately.

Breast-feeding: Dipyridamole passes into breast milk. If you are a breast-feeding mother and are taking dipyridamole, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using this medication have not been established for children.