For knee replacement surgery or hip replacement surgery, the usual dose of Xarelto (Rivaroxaban) is 10 mg taken by mouth, once daily with or without food. Xarelto (Rivaroxaban) is generally started within 6 to 10 hours after the surgery. For hip replacement surgery, the treatment should continue for 35 days. For knee replacement surgery, the treatment should continue for 14 days.

To treat blood clots in the veins of the legs or prevent recurrent blood clots in the lungs or veins of your legs, the recommended starting dose is 15 mg taken two times a day, with food, for 3 weeks. After 3 weeks, the recommended dose is 20 mg taken once a day. The treatments should continue until your physician decides otherwise. After 6 months of treatment for blood clots in the lungs or legs, the dose to continue to prevent blood clots from forming again is 10 mg or 20 mg taken once daily. Your doctor will decide on the dose, depending on your risk of experiencing a new blood clot.

For stroke and clot prevention for people with atrial fibrillation, the usual dose is 20 mg taken by mouth, once daily with food.

To prevent stroke, heart attack, risk of sudden death, or clots blocking blood flow to the legs or arms for people with coronary artery disease, or for people with symptomatic peripheral artery disease the usual dose is 2.5 mg taken by mouth twice daily. One of these doses should be taken at the same time as low-dose ASA.

If you are taking 15 mg or 20 mg at a time, it is suggested that you take Xarelto (Rivaroxaban) with or immediately after food. If you cannot swallow tablets whole, Xarelto (Rivaroxaban) may be crushed and mixed with a small amount of applesauce immediately before taking the medication.

For infants and children under the age of 18 years, Xarelto (Rivaroxaban) oral suspension may be used for the treatment of blood clots in the legs or lungs, or to prevent recurrence of clots in the legs or lungs. The dose is based on body weight. Your doctor will calculate the correct dose and the number of times per day it needs to be given. Xarelto (Rivaroxaban) should be given with feeding or with food.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take Xarelto (Rivaroxaban) exactly as prescribed by your doctor. If you miss a dose of Xarelto (Rivaroxaban) and you are taking the medication once daily, take it as soon as possible and continue with your regular schedule. If you are taking Xarelto (Rivaroxaban) 2.5 mg two times a day, skip the missed dose and continue with your normal schedule. Do not take two doses at once to make up for the missed dose.

If you are taking Xarelto (Rivaroxaban) 15 mg two times a day, take the dose as soon as you remember and continue with your normal schedule. If it is time for your next dose already take 2 tablets (30 mg total) at once, then continue with your normal dosing schedule. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

If your child takes Xarelto (Rivaroxaban) suspension twice daily and has missed the morning dose, take the dose as soon as you remember and continue with your normal schedule. If it is already time for the evening dose, you may give the forgotten dose together with the evening dose. A missed evening dose can only be given if you remember on the same evening.

If your child takes Xarelto (Rivaroxaban) suspension three times daily and has missed a dose, skip the missed dose and continue with your regular dosing schedule. Do not take an extra dose to make up for the missed dose.

If you or your child vomits after taking a dose of Xarelto (Rivaroxaban), and it is less than 30 minutes since taking the dose, take another dose. If you or your child vomit and it is more than 30 minutes since you took the dose, do not take another dose. Take your next dose at its regular time.

Store Xarelto (Rivaroxaban) tablets at room temperature and keep them out of the reach of children. Xarelto (Rivaroxaban) suspension may be stored at room temperature or in the refrigerator for 14 days after being prepared. If storing in the refrigerator, allow it to warm to room temperature before administering it to your child.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.