Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Lupron Depot Kit (Leuprolide).

Depression: Sex hormones influence mood swings and symptoms of depression. If you have depression or a history of depression, discuss with your doctor how Lupron Depot Kit (Leuprolide) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Lupron Depot Kit (Leuprolide), and whether any special monitoring is needed.

Diabetes: Lupron Depot Kit (Leuprolide) may cause a loss of blood glucose control, and glucose tolerance may change. People with diabetes may find it necessary to monitor their blood sugar more frequently while using Lupron Depot Kit (Leuprolide). If you have diabetes or are at risk for developing diabetes, discuss with your doctor how Lupron Depot Kit (Leuprolide) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Lupron Depot Kit (Leuprolide), and whether any special monitoring is needed.

Liver function: In rare cases, Lupron Depot Kit (Leuprolide) has been reported to cause liver failure or inflammation of the liver. If you experience symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin, contact your doctor immediately.

Men and heart-related conditions: There may be an increased risk of heart-related events (e.g., heart attacks, Stroke, heart-related death) for men being treated for prostate cancer with GnRH medications. Before you start treatment, tell your doctor if you have diabetes, heart disease, had a previous Heart Attack or stroke, or have cardiovascular risk factors (e.g., high blood pressure, smoking, or cholesterol). If you have any of these conditions, discuss with your doctor how Lupron Depot Kit (Leuprolide) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Lupron Depot Kit (Leuprolide), and whether any special monitoring is needed.

Osteoporosis: Over time, Lupron Depot Kit (Leuprolide) can cause the bones to lose thickness. People who are at risk for osteoporosis, such as those with a family history of osteoporosis, long-term alcohol or tobacco use, or who are taking other medications that tend to thin bones, such as seizure medications or long-term use of corticosteroids, are more likely to experience this loss of bone. If you have any of these conditions, discuss with your doctor how Lupron Depot Kit (Leuprolide) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Lupron Depot Kit (Leuprolide), and whether any special monitoring is needed.

Seizures: People using Lupron Depot Kit (Leuprolide) have reported experiencing seizures. People who have a history of Epilepsy, medical conditions that increase the risk of seizures, and are taking medications that increase the risk of seizures may be more likely to experience this effect, however people with none of these conditions have also reported seizures. If you have a history of seizures, discuss with your doctor how Lupron Depot Kit (Leuprolide) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Lupron Depot Kit (Leuprolide), and whether any special monitoring is needed.

If you experience a seizure, get emergency medical help.

Starting treatment: During the first few weeks of treatment with Lupron Depot Kit (Leuprolide), you may notice that your signs and symptoms temporarily get worse. This is due to a sudden increase in hormones that will normalize once the right dose for you has been found.

Urinary problems: People with problems urinating due to blockage or narrowing along the urinary tract (obstructive uropathy) may find that starting Lupron Depot Kit (Leuprolide) makes this symptom worse initially. If you have problems with urination, discuss with your doctor how Lupron Depot Kit (Leuprolide) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Lupron Depot Kit (Leuprolide), and whether any special monitoring is needed.

Pregnancy: Lupron Depot Kit (Leuprolide) should not be used during pregnancy. A non-hormonal method of birth control (e.g., condom, diaphragm, IUD) should be used during treatment. If you become pregnant during treatment, notify your doctor as soon as possible.

Breast-feeding: It is not known if Lupron Depot Kit (Leuprolide) passes into breast milk. If you are a breast-feeding mother and are taking Lupron Depot Kit (Leuprolide), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.