Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Anzemet (Dolasetron). If you are concerned about side effects, discuss the risks and benefits of Anzemet (Dolasetron) with your doctor.

The following side effects have been reported by at least 1% of people taking Anzemet (Dolasetron). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• abdominal or stomach pain
• Diarrhea
• dizziness or lightheadedness
• Fever or chills
• headache
• unusual tiredness

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• increased or decreased blood pressure
• pain
• severe stomach pain with nausea or vomiting
• signs of heart problems (e.g., chest pain, fast heartbeat, slow or irregular heartbeat)
• signs of kidney problems (e.g., blood in the urine, decrease in the amount of urine, painful or difficult urination)
• swelling of feet or lower legs

Stop taking the medication and seek immediate medical attention if any of the following occur:

• signs of a Anaphylaxis (severe allergic reaction) (e.g., difficulty breathing; skin rash; Hives or itching; swelling of the eyelids, face, or lips)

Other side effects not listed above may occur in some people. Check with your doctor if you notice any symptom that worries you while you are taking Anzemet (Dolasetron).

Do not take Anzemet (Dolasetron) if you:

• are allergic to Anzemet (Dolasetron) or any ingredients of the medication
• are a surgery patient (for the treatment or prevention of nausea after surgery)
• are under 18 years of age
• are being treated with the medication Apomorphine

There may be an interaction between Anzemet (Dolasetron) and any of the following:

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. In many cases, interactions are intended or are managed by close monitoring. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Anzemet (Dolasetron). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin taking a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should take Anzemet (Dolasetron).

Abnormal heart rhythms: Anzemet (Dolasetron) can cause changes to the rhythm of the heart, which may lead to serious complications, including death. If you have a condition that may make you more likely to develop heart rhythm changes, discuss with your doctor the risks and benefits of taking Anzemet (Dolasetron).

You are more at risk for this type of abnormal heart rhythm and its complications if you:

• are female
• are older than 65 years of age
• have a family history of sudden cardiac death
• have a history of heart disease or abnormal heart rhythms
• have a slow heart rate
• have congenital prolongation of the QT interval
• have Diabetes
• have had a Stroke
• have low potassium, magnesium, or calcium levels
• have nutritional deficiencies
• are taking chemotherapy medications known as anthracyclines (e.g., Doxorubicin, Daunorubicin)
• are taking diuretics ("water pills")

If you have a history of heart disease, abnormal heart rhythms, or are taking medications to treat abnormal heart rhythms, discuss with your doctor how Anzemet (Dolasetron) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Anzemet (Dolasetron), and whether any special monitoring is needed.

Kidney function: Reduced kidney function may cause Anzemet (Dolasetron) to build up in the body, causing side effects. If you have Kidney Disease or reduced kidney function, discuss with your doctor how Anzemet (Dolasetron) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Anzemet (Dolasetron), and whether any special monitoring is needed. Your doctor may want to test your kidney function regularly with blood tests while you are taking this medication.

Liver function: Liver disease or reduced liver function may cause Anzemet (Dolasetron) to build up in the body, causing side effects. If you have liver problems, discuss with your doctor how Anzemet (Dolasetron) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Anzemet (Dolasetron), and whether any special monitoring is needed. Your doctor may want to test your liver function regularly with blood tests while you are taking Anzemet (Dolasetron).

Pregnancy: Anzemet (Dolasetron) should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Anzemet (Dolasetron), contact your doctor immediately.

Breast-feeding: It is not known if Anzemet (Dolasetron) passes into breast milk. If you are a breast-feeding mother and are taking Anzemet (Dolasetron), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using Anzemet (Dolasetron) have not been established for children.

Seniors: Seniors may be more likely to experience side effects related to irregular heart rhythm if they take Anzemet (Dolasetron). Anzemet (Dolasetron) should be avoided by seniors.