Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Signifor (Pasireotide). If you are concerned about side effects, discuss the risks and benefits of Signifor (Pasireotide) with your doctor.

The following side effects have been reported by at least 1% of people taking Signifor (Pasireotide). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• abdominal pain
• altered sense of taste
• bloating
• Constipation
• Diarrhea
• dizziness
• drowsiness
• Dry Mouth
• dry skin
• fatigue
• flushing
• gas
• hair loss
• headache
• indigestion
• itchiness
• loss of appetite
• nausea
• redness, bruising, irritation, or swelling at site of injection
• tremor
• vomiting
• weakness
• weight loss

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• blurred vision
• confusion
• irregular heartbeat
• Low Blood Pressure (dizziness, fainting, lightheadedness)
• muscle and joint pain
• signs of Anemia (low red blood cells; e.g., dizziness, pale skin, unusual tiredness or weakness, shortness of breath)
• signs of clotting problems (e.g., unusual nosebleeds, bruising, blood in urine, coughing blood, bleeding gums, cuts that don't stop bleeding)
• signs of too little cortisol in the body (e.g., weakness, fatigue, loss of appetite, nausea, vomiting, dizziness, low blood sugar)
• signs of heart problems (e.g., fast, irregular heartbeat or pulse; difficulty breathing; weakness; dizziness; fainting; seizures)
• signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
• signs and symptoms of high blood sugar (e.g., frequent urination, increased thirst, excessive eating, unexplained weight loss, poor wound healing, infections, fruity breath odour)
• symptoms of gallstones (e.g., pain in back right shoulder blade, right sided chest pain below rib cage, nausea, vomiting, burping)
• trouble breathing

Stop taking the medication and seek immediate medical attention if any of the following occur:

• seizures
• signs of bleeding in the stomach (e.g., bloody, black, or tarry stools; spitting up of blood; vomiting blood or material that looks like coffee grounds)
• signs of pancreatitis (e.g., abdominal pain on the upper left side, back pain, nausea, Fever, chills, rapid heartbeat, swollen abdomen)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Signifor (Pasireotide).

0.3 mg/mL
Each 1 mL of clear, colourless, sterile solution contains 0.3 mg of Signifor (Pasireotide) as Signifor (Pasireotide) diaspartate. Nonmedicinal ingredients: mannitol, sodium hydroxide, tartaric acid, and water for injection.

0.6 mg/mL
Each 1 mL of clear, colourless, sterile solution contains 0.6 mg of Signifor (Pasireotide) as Signifor (Pasireotide) diaspartate. Nonmedicinal ingredients: mannitol, sodium hydroxide, tartaric acid, and water for injection.

0.9 mg/mL
Each 1 mL of clear, colourless, sterile solution contains 0.9 mg of Signifor (Pasireotide) as Signifor (Pasireotide) diaspartate. Nonmedicinal ingredients: mannitol, sodium hydroxide, tartaric acid, and water for injection.

Do not take Signifor (Pasireotide) if you:

• are allergic to Signifor (Pasireotide) or any ingredients of the medication
• have moderately to severely reduced liver function
• have uncontrolled Diabetes
• have any of the following heart conditions: severe heart failure, cardiogenic shock, AV block, sinoatrial block, sick sinus syndrome, very low heart rate, or long QT syndrome

There may be an interaction between Signifor (Pasireotide) and any of the following:

• acetylsalicylic acid (Asa)
• Alfuzosin
• alpha-agonists (e.g., Clonidine, methyldopa)
• Amiodarone
• antipsychotics (e.g., chlorpromazine, Clozapine, Haloperidol, Olanzapine, Quetiapine, Risperidone)
• Atomoxetine
• "azole" antifungals (e.g., itraconazole, ketoconazole, Voriconazole)
• beta-adrenergic blockers (e.g., Atenolol, Propranolol, sotalol)
• beta-2 agonists (e.g., formoterol, salbutamol, salmeterol)
• Bromocriptine
• Capecitabine
• chloroquine
• Codeine
• Cyclosporine
• diabetes medications (e.g., chlorpropamide, Glyburide, insulin, Metformin, Rosiglitazone)
• Digoxin
• Diltiazem
• Disopyramide
• diuretics (water pills; e.g., Amiloride, Furosemide, Hydrochlorothiazide)
• Domperidone
• Donepezil
• Dronedarone
• Fingolimod
• Flecainide
• Galantamine
• Guanfacine
• HIV protease inhibitors (e.g., darunavir, indinavir, ritonavir, saquinavir)
• hydroxychloroquine
• Ivabradine
• Lacosamide
• Lanreotide
• macrolide antibiotics (e.g., clarithromycin, erythromycin)
• mefloquine
• Methadone
• Midodrine
• mifepristone
• monoamine oxidase inhibitors (M.O.S. e.g., Moclobemide, Phenelzine, Rasagiline, Selegiline, Tranylcypromine)
• Octreotide
• Ondansetron
• pentamidine
• procainamide
• Propafenone
• rilpivirine
• Rivastigmine
• quinidine
• quinine
• quinolone antibiotics (e.g., ciprofloxacin, Norfloxacin, Ofloxacin)
• selective serotonin reuptake inhibitors (SSRIs; e.g., Citalopram, Fluoxetine, Paroxetine, Sertraline)
• siponimod
• testosterone
• Tizanidine
• Tofacitinib
• Tramadol
• tricyclic antidepressants (e.g., Amitriptyline, Clomipramine, Desipramine, Trimipramine)
• tyrosine kinase inhibitors (e.g., Bosutinib, Dasatinib, imatinib, Nilotinib, Sunitinib)
• verapamil
• Warfarin

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Signifor (Pasireotide). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Signifor (Pasireotide).

Abnormal heart rhythms: Signifor (Pasireotide) can cause abnormal heart rhythms. Certain medications (e.g., Sotalol, quinidine, thioridazine, Chlorpromazine, l, Pimozide, moxifloxacin, Mefloquine, pentamidine, arsenic trioxide, Tacrolimus) can increase the risk of a type of abnormal heart rhythm called QT prolongation, and should not be used in combination with Signifor (Pasireotide). You are more at risk for this type of abnormal heart rhythm and its complications if you:

• are female
• are older than 65 years of age
• have a family history of sudden cardiac death
• have a history of heart disease or abnormal heart rhythms
• have a slow heart rate
• have congenital prolongation of the QT interval
• have diabetes
• have had a Stroke
• have low potassium, magnesium, or calcium levels
• have nutritional deficiencies

If you have heart disease and abnormal heart rhythms, or are taking certain medications (e.g., Verapamil, atazanavir), discuss with your doctor how Signifor (Pasireotide) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Signifor (Pasireotide), and whether any special monitoring is needed.

Diabetes: Signifor (Pasireotide) often causes increased blood sugar levels, causing the loss of blood glucose control. Glucose tolerance may change. People with diabetes may find it necessary to monitor their blood sugar more frequently while using Signifor (Pasireotide). Your doctor should monitor your blood glucose levels regularly when you first start using Signifor (Pasireotide), even if you do not have diabetes.

If you have diabetes or are at risk for developing diabetes, discuss with your doctor how Signifor (Pasireotide) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Signifor (Pasireotide), and whether any special monitoring is needed.

Fluid and electrolyte balance: Signifor (Pasireotide) may cause the levels of electrolytes such as potassium, sodium, magnesium, chloride, and calcium in the blood to change while taking Signifor (Pasireotide). If you experience symptoms of fluid and electrolyte imbalance such as muscle pains or cramps; dry mouth; numb hands, feet, or lips; or racing heartbeat, contact your doctor as soon as possible. Your doctor will do blood tests regularly to monitor the levels of these electrolytes in your blood while you are taking Signifor (Pasireotide).

Liver function: People taking Signifor (Pasireotide) may have changes in liver function that produce abnormal liver test results. Your doctor will recommend regular liver tests while you are taking Signifor (Pasireotide). Liver disease or reduced liver function may cause Signifor (Pasireotide) to build up in the body, causing side effects. If you have liver problems, discuss with your doctor how Signifor (Pasireotide) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Signifor (Pasireotide), and whether any special monitoring is needed. Your doctor may want to test your liver function regularly with blood tests while you are taking Signifor (Pasireotide).

If you experience symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin, contact your doctor immediately.

Low levels of cortisol: Treatment with Signifor (Pasireotide) causes a decrease in the amount of cortisol produced by the body. Cortisol is a hormone the body needs to function.

If the amount of cortisol in the body is reduced too much, it can cause weakness, fatigue, loss of appetite, nausea, vomiting, low blood pressure, low blood glucose, and low amounts of sodium in the body.

Pancreatitis: Signifor (Pasireotide) can cause the pancreas to become inflamed. If you have a history of pancreatitis, discuss with your doctor how Signifor (Pasireotide) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Signifor (Pasireotide), and whether any special monitoring is needed.

Report signs of pancreatitis such as abdominal pain on the upper left side, back pain, nausea, fever, chills, rapid heartbeat, or swollen abdomen to your doctor immediately.

Pregnancy: The potential risks of using Signifor (Pasireotide) during pregnancy, for the mother or developing baby, are not known. Women who may become pregnant should not use Signifor (Pasireotide) unless they are using reliable birth control. If you become pregnant while taking Signifor (Pasireotide), contact your doctor immediately.

Breast-feeding: It is not known if Signifor (Pasireotide) passes into breast milk. If you are a breast-feeding mother and are taking Signifor (Pasireotide), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using Signifor (Pasireotide) have not been established for children.