Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Crinone (Progesterone-vaginal).

Blood clots: Crinone (Progesterone-vaginal) may cause blood clots. If you experience pain, swelling, or redness in your calf or leg; chest pain; shortness of breath; difficulty breathing; eye pain or vision changes; get immediate medical attention.

Depression: Hormones, such as progesterone, have been known to cause mood swings and symptoms of depression. If you have depression or a history of depression, discuss with your doctor how Crinone (Progesterone-vaginal) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Crinone (Progesterone-vaginal), and whether any special monitoring is needed.

If you experience symptoms of depression such as poor concentration, changes in weight, changes in sleep, decreased interest in activities, or notice them in a family member who is taking Crinone (Progesterone-vaginal) contact your doctor as soon as possible.

Diabetes: Progesterone may cause an increase in blood sugar levels (may cause a loss of blood glucose control) and glucose tolerance may change. People with diabetes may find it necessary to monitor their blood sugar more frequently while using Crinone (Progesterone-vaginal).

Drowsiness/reduced alertness: Progesterone may cause drowsiness. Do not drive or operate machinery until you know how Crinone (Progesterone-vaginal) affects you.

Fluid retention: Progesterone can cause fluid retention. If you have Epilepsy, migraines, Asthma, or heart or kidney problems, discuss with your doctor how Crinone (Progesterone-vaginal) may affect your medical condition and whether any special monitoring is needed.

Heart attack: The risk of heart attack is increased with the use of progesterone, due to the increased risk of blood clots. If you experience symptoms of heart attack, such as sudden chest pain or pressure on the chest, a sense of dread, difficulty breathing, nausea or pain radiating from the shoulder to the jaw or arm, seek immediate medical help.

Liver: Crinone (Progesterone-vaginal) may cause liver problems. If you experience yellowing of the skin or eyes, nausea, vomiting, abdominal pain, light-coloured stools, or dark urine, contact your doctor. Your doctor will monitor your liver function while you are using this medication.

Other vaginal medications: Progesterone vaginal gel or tablets should not be used at the same time as other vaginal medications or products. Wait at least 6 hours after using progesterone vaginal gel before using other vaginal medications or products.

Stroke: Crinone (Progesterone-vaginal) increases the risk of a stroke occurring. If you experience signs of a stroke, such as confusion, difficulty speaking, loss of coordination, sudden headache or vision changes, contact your doctor as soon as possible.

Vaginal bleeding: If you experience vaginal bleeding while using Crinone (Progesterone-vaginal), contact your doctor.

Pregnancy: Crinone (Progesterone-vaginal) can be used for up to 10 to 12 weeks to maintain pregnancy.

Breast-feeding: This medication may pass into breast milk. If you are a breast-feeding mother and are using vaginal progesterone, it may affect your baby. Breast-feeding is not recommended while you are using Crinone (Progesterone-vaginal).

Children: The safety and effectiveness of using Crinone (Progesterone-vaginal) have not been established for children. Crinone (Progesterone-vaginal) is not intended for use by children.

Seniors: Crinone (Progesterone-vaginal) is intended for use by women of child-bearing age. Its safety and effectiveness have not been established for seniors.