Rapamune (Sirolimus) is an immunosuppressant agent. It is normally used along with corticosteroid medications and Cyclosporine to prevent the rejection of kidney organ transplants.
Available form
Tablet, Liquid
Manufacturer
Pfizer
Dosage
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Rapamune (Sirolimus) is normally started as soon as possible after transplant. The dose prescribed will depend on your situation. The recommended first dose of Rapamune (Sirolimus) for new transplant recipients is 6 mg followed by a regular dose of 2 mg daily. For people who have previously had a transplant rejection or are at high risk of rejecting the transplant, the first dose is often 15 mg with a regular dose of 5 mg per day.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are using the medication without consulting your doctor.
Do not stop taking Rapamune (Sirolimus) without talking with your doctor.
Rapamune (Sirolimus) is normally given along with cyclosporine and corticosteroids. Rapamune (Sirolimus) should be taken approximately 4 hours after the cyclosporine.
Rapamune (Sirolimus) should be taken at the same time each day, and taken the same way, either with or without food. It should not be taken with grapefruit juice.
Rapamune (Sirolimus) is available as an oral (by mouth) solution and in tablet form. If you are taking the tablets, do not crush, chew, or split them.
The oral solution bottles have oral dose syringes which should be used to withdraw the prescribed amount of Rapamune (Sirolimus) from the bottle. Empty the correct amount of Rapamune (Sirolimus) from the syringes into a glass or plastic container holding at least 2 ounces (60 mL) of water or orange juice. No other liquids should be used for dilution. Stir vigorously and drink at once. Rinse the container with an additional volume (minimum of 4 ounces or 120 mL) of water or orange juice, stir vigorously, and drink at once. This ensures that all the medication is rinsed from the container and that the entire dose is taken.
The preparation should be used immediately after dilution and the syringe discarded after one use.
Rapamune (Sirolimus) solutions provided in bottles may develop a slight haze when refrigerated. If this occurs, allow the bottle to stand at room temperature and shake gently until the haze disappears. The presence of this haze does not affect the quality of the product.
Do not allow water or juice to contaminate the medication in the bottle. If the mouth of the bottle needs to be cleaned, wipe the bottle with a dry cloth.
The tablets should only be taken with water or orange juice.
It is extremely important to take Rapamune (Sirolimus) exactly as prescribed, since missing even a few doses of Rapamune (Sirolimus) may cause your body to reject the organ. Check with your doctor or pharmacist for the proper way to take Rapamune (Sirolimus).
If you miss a dose, take the missed dose as soon as you remember, but not within 4 hours of your cyclosporine dose. If it is less than four hours until your next scheduled dose of Rapamune (Sirolimus), skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Store Rapamune (Sirolimus) solution in the refrigerator, protect it from light, and keep it out of the reach of children. Once the bottle is opened, it should be kept in a refrigerator and the contents used within one month. If left at room temperature, the opened bottle must be used within 5 days. If the amber syringe is pre-filled, it may be kept at room temperature or in the refrigerator for a maximum of 24 hours.
Store Rapamune (Sirolimus) tablets at room temperature (15°C to 30°C), protect them from light and moisture, and keep out of the reach of children.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
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*Actual pricing may differ. Medication is only available by prescription. The cost may be subsidised by your provincial or private health plan.
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