There may be an interaction between Lysodren (Mitotane) and any of the following:

• Abiraterone
• alpha blockers (e.g., Alfuzosin, Doxazosin, Tamsulosin)
• amiodaroneanti-cancer medications (e.g., Docetaxel, Doxorubicin, Irinotecan, Vincristine)
• antipsychotics (e.g., Aripiprazole, Clozapine, Haloperidol)
• Apixaban
• Apremilast
• "azole" antifungals (e.g., itraconazole, ketoconazole, Voriconazole)
• benzodiazepines (e.g., Alprazolam, Clonazepam, Diazepam)
• Bisoprolol
• Buspirone
• Calcitriol
• calcium channel blockers (e.g., Amlodipine, Diltiazem, Nifedipine, Verapamil)
• cannabis
• Carbamazepine
• chloroquine
• Cobicistat
• conivaptan
• corticosteroids (e.g., beclomethasone, Dexamethasone, Prednisone)
• Cyclosporine
• Dapsone
• Darifenacin
• Disopyramide
• Dronedarone
• Enzalutamide
• estrogens (e.g., conjugated estrogen, Estradiol, ethinyl estradiol)
• Fesoterodine
• "gliptin" Diabetes medications (e.g., Linagliptin, Saxagliptin, Sitagliptin)
• hepatitis medications (e.g., asunaprevir, boceprevir, daclatasvir)
• HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs; e.g., delavirdine, efavirenz, etravirine, nevirapine)
• HIV protease inhibitors (e.g., atazanavir, indinavir, ritonavir, saquinavir)
• Idelalisib
• Losartan
• macrolide antibiotics (e.g., clarithromycin, azithromycin)
• maraviroc
• Mefloquine
• Methadone
• narcotic pain relievers (e.g., Codeine, Fentanyl, Morphine, Oxycodone)
• nefazodone
• nitrates (isosorbide dinitrate, isosorbide mononitrate)
• Ondansetron
• Perampanel
• phosphodiesterase 5 inhibitors (e.g., Sildenafil, Tadalafil, Vardenafil)
• praziquantel
• Primaquine
• progestins (e.g., Dienogest, Levonorgestrel, medroxyprogesterone, Norethindrone)
• protein kinase inhibitors (e.g., Dabrafenib, Dasatinib, imatinib)
• proton pump inhibitors (e.g., Lansoprazole, Omeprazole)
• quinidine
• quinine
• rifabutin
• rivroxaban
• Roflumilast
• Romidepsin
• selective serotonin reuptake inhibitors (SSRIs; e.g., Citalopram, Fluoxetine, Paroxetine, Sertraline)
• serotonin-norepinephrine reuptake inhibitors (SNRIs; Desvenlafaxine, Duloxetine, Venlafaxine)
• Solifenacin
• Spironolactone
• "statin" anti-cholesterol medications (e.g., Atorvastatin, Lovastatin, Simvastatin)
• Tamoxifen
• Tetracycline
• Ticlopidine
• Ticagrelor
• tofactitinib
• Tolvaptan
• Trazodone
• Trimethoprim
• Ulipristal
• warfrain
• Zolpidem
• Zopiclone

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Lysodren (Mitotane). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.