The recommended dose and dosing schedule of mitomycin varies according to the specific condition being treated, the response to therapy, and other medications or treatments being used. The dose administered is also based on body size. Mitomycin is usually injected into a vein but can also be instilled intravesically (into the bladder) for treatment of bladder cancer.

When intravesicle treatment is performed, your doctor will likely advise you not to drink fluids for 12 hours prior to the procedure. The solution is usually maintained in the bladder for 2 hours. Very careful handling of Mitomycin (Mitomycin-c) is required. It is always given under the supervision of a doctor in a hospital or similar setting with access to sterile equipment for preparation.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications.

As well as interfering with the genetic material DNA of cancer cells, mitomycin can interfere with some of your normal cells. This can cause a number of side effects such as mouth sores. Mitomycin may cause nausea and vomiting, but it is important to keep using Mitomycin (Mitomycin-c) even if you feel ill.

Your doctor, nurse, or pharmacist can advise you on how to reduce the effects of nausea and vomiting. Keep track of any side effects and report them to your doctor as suggested in the section, "What side effects are possible with Mitomycin (Mitomycin-c)?"

It is important Mitomycin (Mitomycin-c) be given exactly as recommended by your doctor. If you miss an appointment to receive mitomycin, contact your doctor as soon as possible to reschedule your appointment.

Mitomycin (Mitomycin-c) should be stored at room temperature and protected from light.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.