Humira (Adalimumab) belongs to the class of medications called biological response modifiers ("biologics") or TNF blockers (tumor necrosis factor blockers). It is used to treat: moderate-to-severe Rheumatoid Arthritis moderate-to-severely-activepolyarticular juvenile idiopathic arthritis (JIA) for children andadolescents from 2 to 17 years of age who have not responded adequately toother treatments active Psoriatic Arthritis thathas not responded to treatment with Methotrexate ankylosing spondylitis inadults who have not responded to other treatments moderate-to-severe Crohn's Disease in adults who have not responded to other treatments severely active Crohn's diseasein adolescents 13 to 17 years of age, weighing more than40 kg, who have not responded adequately to other treatments moderate-to-severely activeulcerative colitis (UC) in adults who have not responded adequately to orcannot tolerate other treatments moderate-to-severe plaquepsoriasis in adults moderate-to-severe hidradenitissuppurativa (HS), an inflammatory disease of the skin, in adults andadolescents 12 years of age and older who weigh more than 30 kg who havenot responded to treatment with antibiotics non-infectious uveitis (aninflammatory disease of the eye) in adults who have not responded tocorticosteroids chronic non-infectious uveitisaffecting the front of the eye in children over 2 years old who have notresponded adequately to or cannot tolerate other treatments People with these immune conditions produce extra amounts of an inflammatory protein called tumour necrosis factor alpha (TNF-alpha), causing pain, inflammation, and cellular damage.
Available form
Injectable
Manufacturer
Abbvie Corporation, Celltrion Healthcare, Sandoz
Dosage
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Humira (Adalimumab) is given by subcutaneous (under the skin) injection, usually in the front of the thigh or abdomen. The dose depends on the condition being treated.
For rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis, the recommended dose for adults is 40 mg every other week.
For adults with Crohn's disease or Ulcerative Colitis, the recommended dose is a first dose of 160 mg, then 80 mg 2 weeks after the first dose, then 40 mg every second week starting 4 weeks after the first dose.
For adults with psoriasis or uveitis, the recommended dose is a first dose of 80 mg, then 40 mg every other week starting one week after the first dose.
For children over 2 years old with uveitis, the dose of Humira (Adalimumab) is 20 mg every other week for children who weigh less than 30 kg and 40 mg every other week for children who weigh 30 kg or more.
When treating polyarticular juvenile idiopathic arthritis in children over 2 years old, the dose of Humira (Adalimumab) is 20 mg every other week for children who weigh 10 kg to less than 30 kg. For children who weigh 30 kg or more, the dose is 40 mg given every other week.
For Crohn's disease affecting children 13 to 17 years of age weighing more than 40 kg, the recommended starting dose is 160 mg the first week, 80 mg given at week 2 and then 20 mg every second week, starting on week 4. The dose may be increased to 40 mg every other week depending on your child's response.
For hidradenitis suppurativa in adults, the recommended dose is a first dose of 160 mg, then 80 mg 2 weeks after the first dose, then 40 mg every week starting 4 weeks after the first dose. For adolescents 12 years of age and older and weighing more than 30 kg, the recommended dose is a first dose of 80 mg, then 40 mg every other week starting 1 week later. Humira (Adalimumab) is used with the guidance and supervision of a doctor. Your doctor or nurse will assist you in the preparation and injection of your first dose (or first few doses). Do not attempt to inject Humira (Adalimumab) on your own until you completely understand how to inject a dose. If you are having difficulty giving yourself injections, ask a family member or other caregiver for help if they are willing to become involved with your treatment and are willing to learn how to give you your injections.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are using the medication without consulting your doctor.
It is important to use Humira (Adalimumab) exactly as prescribed by your doctor. If you miss a dose, administer it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Store Humira (Adalimumab) in the refrigerator at 2°C to 8°C, protect it from light, and keep it out of the reach of children. Do not allow it to freeze. The pen or pre-filled syringe may also be stored at room temperature (up to a maximum of 25°C) for a single period of 14 days. If it is stored at room temperature and is not used within 14 days, it must be discarded.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
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