Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Trusopt (Dorzolamide). If you are concerned about side effects, discuss the risks and benefits of Trusopt (Dorzolamide) with your doctor.

The following side effects have been reported by at least 1% of people taking Trusopt (Dorzolamide). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• bitter taste after putting in your eye drops
• burning, stinging, or discomfort when eye drops are used
• crusting on eyelid or corner of the eye
• Dry Mouth
• eye discharge
• headache
• nausea
• nosebleed
• redness of the eyes
• tearing (eyes produce excess teardrops)
• unusual tiredness or weakness

Although most of these side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• blurred vision
• dizziness
• eye pain
• feeling of something in the eye
• itching, redness, swelling, or other signs of eye or eyelid irritation
• sensitivity of the eye to sunlight
• skin rash
• symptoms of Kidney Stones (e.g., blood in urine; nausea or vomiting; pain in side, back, or abdomen)
• tingling in the extremities (hands or feet)

Stop taking the medication and seek immediate medical attention if any of the following occur:

• symptoms of an allergic reaction (e.g., difficulty breathing, Hives, itchy and raised skin rash, or swelling of the mouth and throat)
• symptoms of severe skin reaction (e.g., skin blisters, severe red or purple rash or itching, skin lesions and sores, Fever, or sore throat)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Trusopt (Dorzolamide).

2%
Each 1 mL of sterile, clear, colourless-to-nearly-colourless ophthalmic solution contains Trusopt (Dorzolamide) 20 mg (2%). Nonmedicinal ingredients: benzalkonium chloride (as a preservative), hydroxyethylcellulose, mannitol, sodium citrate dihydrate, sodium hydroxide (to adjust pH), and water for injection.

2% preservative-free
Each 1 mL of sterile, clear, colourless-to-nearly-colourless ophthalmic solution contains Trusopt (Dorzolamide) 20 mg (2%). Nonmedicinal ingredients: hydroxyethyl cellulose, mannitol, sodium citrate dihydrate, sodium hydroxide (to adjust pH), and water for injection.

Trusopt (Dorzolamide) should not be used by anyone who:

• is allergic to Trusopt (Dorzolamide) or to any of the ingredients of the medication
• is taking carbonic anhydrase inhibitors (e.g., Acetazolamide) by mouth
• has severe kidney impairment

There may be an interaction between Trusopt (Dorzolamide) and any of the following:

• high doses of acetylsalicylic acid (Asa)
• other carbonic anhydrase inhibitors (e.g., acetazolamide)

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Trusopt (Dorzolamide). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Trusopt (Dorzolamide).

Allergy: Trusopt (Dorzolamide) belongs to the family of medications known as sulfonamides or "sulfas." The same type of allergic reaction can occur with Trusopt (Dorzolamide) as with other sulfonamides. People with allergies to sulfonamides should discuss with their doctor the risks and benefits of using Trusopt (Dorzolamide). Stop using Trusopt (Dorzolamide) and contact your doctor if you experience symptoms of an allergic reaction (e.g., difficulty breathing, hives, skin rash, swelling of the mouth and throat).

Blurred vision: Side effects such as blurred vision may affect the ability to drive and operate machinery. Do not drive, operate machinery, or engage in any potentially hazardous activities until you determine how Trusopt (Dorzolamide) affects you.

Choroidal detachment: Anyone with chronic or recurrent choroidal detachment should talk to their doctor about further use of the eye drop.

Contact lenses: If you wear contact lenses, remove the lenses before using the eye drops and wait at least 15 minutes before re-inserting them.

Eye surgery, eye (corneal) defect, infections, trauma: Anyone using Trusopt (Dorzolamide) who has had eye surgery, pre-existing long-term eye (corneal) defect, trauma to the eye, or who has symptoms of an eye infection (e.g., eye redness, itchiness, discharge, crusts on the eyelids, or the feeling of something in the eye) should contact their doctor concerning further use of the eye drop.

General: As with other topically applied eye drops, Trusopt (Dorzolamide) may be absorbed into the bloodstream. The same side effects reported with oral medications such as carbonic anhydrase inhibitors (e.g., acetazolamide, Methazolamide) or sulfonamides (e.g., sulfamethoxazole) may occur with the eye drops. These side effects may include, but are not limited to, rash and nausea. Refer to the "What side effects are possible with Trusopt (Dorzolamide)?" section for more information.

Kidney Disease: If you have kidney disease, discuss with your doctor how Trusopt (Dorzolamide) may affect their medical condition, how your medical condition may affect the dosing and effectiveness of Trusopt (Dorzolamide), and whether any special monitoring is needed. People with severe kidney impairment should not use Trusopt (Dorzolamide).

Liver disease: If you have liver disease, discuss with your doctor how Trusopt (Dorzolamide) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Trusopt (Dorzolamide), and whether any special monitoring is needed.

Pregnancy: Trusopt (Dorzolamide) should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Trusopt (Dorzolamide), contact your doctor immediately.

Breast-feeding: It is not known if Trusopt (Dorzolamide) passes into breast milk. If you are a breast-feeding mother and are taking Trusopt (Dorzolamide), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.