Siliq (Brodalumab) belongs to the class of medications called biological response modifiers ("biologics"). It is used to treat moderate-to-severe plaque psoriasis in adults whose specialists have determined that systemic or phototherapy may be beneficial.
Available form
Injectable
Dosage
Manufacturer
Bausch Health
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The recommended starting dose of Siliq (Brodalumab) is 210 mg injected subcutaneously (under the skin) once a week for 3 weeks. After 3 doses, the recommended dose is 210 mg injected every 2 weeks. Each dose is given as a single injection of 210 mg (1.5 mL). Each syringe is single-use only and should be safely discarded after injecting the dose.
Siliq (Brodalumab) is administered by subcutaneous injection in the thigh, abdomen, or outer upper arm. It is important to rotate the site of injection. Avoid injecting into areas that are tender, bruised, red, hard, or affected by psoriasis.
Do not shake Siliq (Brodalumab) before using it. The solution for injection should be clear to slightly opalescent, and colourless-to-slightly-yellow. If it is cloudy or you can see lumps, flakes, or coloured particles in the solution, do not use it. To minimize discomfort, allow Siliq (Brodalumab) to warm to room temperature for 30 minutes before injecting.
If you are using Siliq (Brodalumab) at home, your doctor will ensure that you understand exactly how to use it. Make sure you ask any and all questions necessary to ensure that you use it exactly as prescribed. It is important to visit your doctor regularly during therapy to ensure that the medication is working safely and effectively.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
It is important to take Siliq (Brodalumab) exactly as prescribed by your doctor.
If you miss a dose, inject it as soon as possible. Then talk to your doctor about when you should inject the next dose. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Store Siliq (Brodalumab) in the refrigerator, protect it from light and moisture, and keep it out of the reach of children. Do not allow Siliq (Brodalumab) to freeze. Siliq (Brodalumab) may also be kept at room temperature in its original carton for up to 14 days.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who takes Siliq (Brodalumab). If you are concerned about side effects, discuss the risks and benefits of Siliq (Brodalumab) with your doctor.
The following side effects have been reported by at least 1% of people taking Siliq (Brodalumab). Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Stop taking the medication and seek immediate medical attention if any of the following occur:
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Siliq (Brodalumab).
Each 1 mL of clear-to-slightly-opalescent, colourless-to-slightly-yellow liquid that is practically free from particles, contains 140 mg of Siliq (Brodalumab). Nonmedicinal ingredients: proline, glutamate, polysorbate 20, and water for injection. The resulting pH is 4.8.
Each single-use prefilled syringe contains 210 mg of Siliq (Brodalumab) and is supplied in 1.5 mL solution (140 mg/mL Siliq (Brodalumab)) in a single-use syringe made from type 1 glass with a stainless steel 27G x 1⁄2" needle.
Do not take Siliq (Brodalumab) if you:
There may be an interaction between Siliq (Brodalumab) and any of the following:
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with Siliq (Brodalumab). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Siliq (Brodalumab).
Allergic reactions: In rare cases, some people may develop an allergic reaction to Siliq (Brodalumab). Signs of an allergic reaction include a severe rash, Hives, swollen face or throat, or difficulty breathing. If these occur, seek medical attention immediately.
Crohn's Disease: If you have Crohn's disease, (a form of inflammatory bowel disease) Siliq (Brodalumab) may make symptoms of this condition worse. During medication testing, some people with no history of Crohn's disease developed bowel symptoms. If you develop symptoms of inflammation in the digestive system, such as diarrhea, fatigue, fever, and abdominal pain or cramping, contact your doctor as soon as possible. People who have Crohn's disease should not use Siliq (Brodalumab).
Infections: Siliq (Brodalumab) can increase the risk of developing an infection, including serious infections such as sepsis, pneumonia, and Tuberculosis. Before starting Siliq (Brodalumab) treatment, your doctor may test to see if you have tuberculosis. If you notice signs of an infection such as fever, chills, pain, swelling, coughing, or pus, contact your doctor as soon as possible. Siliq (Brodalumab) should also not be started while you have an active infection.
Tell your doctor if you have a history of infections that keep coming back, or other conditions that might increase your risk of infections such as Diabetes. While you are taking Siliq (Brodalumab), your doctor will monitor you for signs of infection.
Suicidal or agitated behaviour: People with psoriasis appear to be at an increased risk of suicidal behaviour. If you have Depression or other mental illness, you may be at an increased risk of mood changes, feeling agitated (restless, anxious, aggressive, emotional, and feeling not like themselves), or wanting to hurt yourself or others. If you experience these side effects or notice them in a family member who is taking Siliq (Brodalumab), contact your doctor immediately.
Vaccines: Live vaccines (e.g., BCG, yellow fever) are not recommended for people taking Siliq (Brodalumab). Talk to your doctor if you need any vaccinations while taking Siliq (Brodalumab).
Pregnancy: Siliq (Brodalumab) should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Siliq (Brodalumab), contact your doctor immediately.
Breast-feeding: It is not known if Siliq (Brodalumab) passes into breast milk. If you are a breast-feeding mother and are taking Siliq (Brodalumab), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of using Siliq (Brodalumab) have not been established for children.
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