Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent. The side effects listed below are not experienced by everyone who uses Prostin VR (Alprostadil). If you are concerned about side effects, discuss the risks and benefits of Prostin VR (Alprostadil) with your baby's doctor.

While your baby is receiving Prostin VR (Alprostadil), health care professionals in the hospital will be monitoring your baby for any possible side effects. The following side effects have been reported by at least 1% of people using Prostin VR (Alprostadil). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if your baby experiences these side effects and they are severe or bothersome.

• apnea (episodes of regular breathing with pauses)
• Diarrhea
• Fever
• flushing
• infections
• Low Blood Pressure (symptoms include dizziness or fainting)
• slow or fast heartbeat
• spitting up
• swelling of the arms, feet, or legs

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not check with your baby's doctor or seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• abnormal heart rhythm
• Blood Clots
• blood in urine
• bluish skin colour
• convulsions or seizures
• feeling drowsy or sluggish
• hypothermia (abnormally low body temperature; e.g., shivering, shallow breathing, drowsiness, loss of consciousness)
• irritability or jitteriness
• low blood sugar levels (e.g., dizziness, lack of energy, sweating, or shakiness)
• low potassium levels (e.g., weakness, muscle cramps, Constipation, nausea or vomiting, heart palpitations, increased thirst or urination, tingling or numbness)
• stiffness

Stop the medication and seek immediate medical attention if any of the following occur:

• bleeding
• cardiac arrest
• signs of a serious allergic reaction (e.g., shortness of breath or difficulty breathing; Hives; swelling of the eyes, mouth, lips, or throat)
• troubled breathing or stopped breathing

Some people may experience side effects other than those listed. Check with your baby's doctor if you notice any symptom that worries you while your baby is on Prostin VR (Alprostadil).

Each 1 mL ampule contains Prostin VR (Alprostadil) 500 µg in anhydrous ethanol.

Prostin VR (Alprostadil) should not be used by anyone who:

• is allergic to Prostin VR (Alprostadil) or to any of the ingredients of the medication
• has certain heart or lung conditions which, in their doctor's judgment, would make it dangerous for them to use Prostin VR (Alprostadil)

If your baby is taking any other medications or supplements, speak with your doctor or pharmacist. Depending on the specific circumstances, the doctor may recommend:

• stopping one of the medications,
• changing one of the medications to another,
• changing how one or both of the medications are being taken, or
• leaving everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Before your baby begins using a medication, be sure to inform your doctor of any medical conditions or Allergies your baby may have, any medications your baby is taking, and any other significant facts about your health. These factors may affect how your baby will receive Prostin VR (Alprostadil).

Bleeding disorders: If your baby has a bleeding disorder, discuss this with your baby's doctor to see how Prostin VR (Alprostadil) may affect your baby's medical condition, how their medical condition may affect the dosing and effectiveness of Prostin VR (Alprostadil), and whether any special monitoring is needed.

Hospital use: Prostin VR (Alprostadil) should only be given by a trained health care professional in a hospital setting.

Lung problems: If your baby has any lung problems, discuss this with your baby's doctor to see how Prostin VR (Alprostadil) may affect your baby's medical condition, how their medical condition may affect the dosing and effectiveness of Prostin VR (Alprostadil), and whether any special monitoring is needed.

Other heart problems: If your baby has other heart problems or low blood pressure, discuss this with your baby's doctor to see how Prostin VR (Alprostadil) may affect your baby's medical condition, how their medical condition may affect the dosing and effectiveness of Prostin VR (Alprostadil), and whether any special monitoring is needed.