Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent. The side effects listed below are not experienced by everyone who takes Muse (Alprostadil-urogenital). If you are concerned about side effects, discuss the risks and benefits of Muse (Alprostadil-urogenital) with your doctor.

The following side effects have been reported by at least 1% of people taking Muse (Alprostadil-urogenital). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• dizziness
• flu-like symptoms or general body aches
• infection
• lowering of blood pressure
• mild bleeding or spotting from urethra
• pain at site of insertion
• pain of the penis, urethra, or testes
• painful erection
• runny nose
• stinging of urethra
• vaginal itching and burning (in female partners of men taking alprostadil for erectile dysfunction; it is unknown whether these side effects are a result of the medication itself)

Although most of these side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• fainting
• rapid pulse
• swelling or pain in the testes

Stop taking the medication and seek immediate medical attention if any of the following occur:

• curving of penis with pain during erection
• priapism (erection that lasts over 6 hours with severe and continuing pain of the penis)
• prolonged erection (lasting for 4 to 6 hours)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Muse (Alprostadil-urogenital).

250 µg
Each transurethral delivery system contains alprostadil 250 µg. Nonmedicinal ingredients: polyethylene glycol 1450 USP.

500 µg
Each transurethral delivery system contains alprostadil 500 µg. Nonmedicinal ingredients: polyethylene glycol 1450 USP.

1,000 µg
Each transurethral delivery system contains alprostadil 1,000 µg. Nonmedicinal ingredients: polyethylene glycol 1450 USP.

Do not use alprostadil suppositories if:

• you are allergic to alprostadil or any of the ingredients of the medication
• you are a woman or child
• you are prone to venous thrombosis
• you have an anatomical deformation of the penis, such as angulation, cavernosal fibrosis, or Peyronie's disease
• you have a condition that increases the risk of priapism, such as sickle cell Anemia, Multiple Myeloma, or Leukemia
• you have a penile implant
• you have priapism (a condition where erections are painful and last for over 6 hours)
• your doctor has advised you not to have sex
• your sexual partner is pregnant (unless a condom is used)

There may be an interaction between alprostadil (MUSE) and any of the following:

• anticoagulants (e.g., Warfarin, Heparin)
• blood pressure medications (for high blood pressure)
• other medications that act on the blood vessels (including those taken by mouth to enhance or cause an erection)
• phosphodiesterase-5 inhibitors (e.g., Sildenafil, Tadalafil, Vardenafil)

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Muse (Alprostadil-urogenital). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Muse (Alprostadil-urogenital).

Bleeding: If the medication is not inserted properly, you may have small cuts or scrapes in the urethra. People with bleeding disorders or those taking blood thinners may be at a higher risk of bleeding and should be closely monitored by their doctor while they are taking Muse (Alprostadil-urogenital). The small cuts or scrapes in the urethra also increases the risk of passing sexually transmitted infections between sexual partners.

Fainting: Fainting may occur up to one hour after the medication is inserted. Avoid activities such as driving or operating machinery during this time.

Prolonged erections: If your erection lasts for 2 hours, try to reduce the erection by methods suggested by your doctor (such as applying ice packs to the inner thighs). If your erection lasts for 4 hours or more, call your doctor immediately.

Women and children: Muse (Alprostadil-urogenital) is not recommended for women or children. Men who are having intercourse with a pregnant woman should use a condom to protect the developing child from being exposed to Muse (Alprostadil-urogenital).