The MUSE system uses an applicator to insert a pellet of medication into the urethra (the tube that urine passes through in the penis). This is usually done just after urination. The pellet then dissolves and the medication enters the blood-filled spaces of the penis (corpora cavernosa), where it works to cause an erection.

Your doctor will choose the appropriate dose of alprostadil for you.Once the correct dose has been found, the doctor will teach you to insert the medication properly. Once your doctor is assured that you are comfortable with the procedure, you will be given a prescription for a kit to use at home. Please refer to the package insert for details on how to use the medication properly.

The usual starting dose of alprostadil is 250 µg, and depending on your response to the medication, it may be increased up to 1,000 µg as directed by your doctor. The medication should not be used more than twice in a 24-hour period. The applicator should be used only once and then discarded safely. For best results, sit, stand, or walk for the first 10 minutes after you use the medication.

If the erection lasts for 2 hours, try to reduce the erection by methods suggested by your doctor. A prolonged erection (4 hours or more) should be reported to your doctor immediately.

Do not insert alprostadil into an erect penis. Never increase or decrease the dose without consulting your doctor. It is important to visit your doctor regularly, at least every 3 months during therapy, to ensure that the medication is working safely and effectively.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are using the medication without consulting your doctor.

It is important to use Muse (Alprostadil-urogenital) exactly as prescribed by your doctor.

Store unopened foil pouches in a refrigerator. Do not expose Muse (Alprostadil-urogenital) to temperatures over 30°C. MUSE can be stored at room temperature (below 30°C) for up to 14 days prior to use. Protect Muse (Alprostadil-urogenital) from light and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.