Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Hycamtin (Topotecan).

Anemia: Hycamtin (Topotecan) may cause low levels of red blood cells. If you experience symptoms of reduced red blood cell count (anemia) such as shortness of breath, feeling unusually tired, or pale skin, contact your doctor as soon as possible.

Your doctor will do blood tests regularly to monitor the number of specific types of blood cells, including red blood cells, in your blood.

Blood clotting: Hycamtin (Topotecan) can reduce the number of platelet cells in the blood. Platelets help the blood to clot, and a shortage could make you bleed more easily. Tell your doctor of any signs that your blood is not clotting as quickly. Such symptoms may include black and tarry stools, blood in the urine, easy bruising, or cuts that won't stop bleeding.

Extravasation: Hycamtin (Topotecan) may be irritating to your veins while it is being administered. Please let your nurse know immediately if you feel any burning or pain at the injection site while the medication is being given.

Infection: As well as killing cancer cells, Hycamtin (Topotecan) can reduce the number of cells that fight infection in the body (white blood cells). If possible, avoid contact with people who have contagious infections. Tell your doctor immediately if you begin to notice signs of an infection, such as fever or chills, severe diarrhea, shortness of breath, prolonged dizziness, headache, stiff neck, weight loss, or listlessness. Your doctor will do blood tests regularly to monitor the number of specific types of blood cells in your blood.

Lung inflammation: Hycamtin (Topotecan) can cause lung inflammation, especially for people with a history of lung problems (e.g., fibrosis, lung cancer, chest radiation). This can be serious and sometimes fatal. If you experience cough, fever, or shortness of breath, contact your doctor immediately.

Neutropenic colitis: Hycamtin (Topotecan) can cause neutropenic colitis, which is an inflammation of the colon associated with a decrease in white blood cells. If you experience abdominal pain with fever, seek immediate medical attention.

Weakness/tiredness: Hycamtin (Topotecan) is not expected to make you drowsy and impair your ability to drive or use machinery. However, it may make some people feel weak or tired. Do not drive or use machinery if you feel weak or tired.

Pregnancy: There is a possibility of birth defects with Hycamtin (Topotecan) if it is taken during pregnancy. Effective birth control should be practiced while using Hycamtin (Topotecan). If you become pregnant while taking Hycamtin (Topotecan), contact your doctor immediately.

Breast-feeding: It is not known if Hycamtin (Topotecan) passes into breast milk. Women who are receiving Hycamtin (Topotecan) should not breast-feed.

Children: The safety and effectiveness of using Hycamtin (Topotecan) have not been established for children.