The usual adult dose of Colestid (Colestipol) ranges from 2 g to 16 g daily for the tablets, or 5 g to 30 g daily for the granules and orange granules, depending on circumstances. The medication may be given in a single dose or in divided doses.

The tablets should be swallowed whole and not cut, chewed, or crushed. The prescribed amount of tablets can be taken with water or other fluids. The tablets should be taken with meals.

The granules should be added to at least 100 mL of water, milk, flavoured drink, juice, or carbonated beverage. A heavy or pulpy juice may also be used. The mixture should be stirred well until the medication is completely suspended in the liquid. The granules and orange granules will not dissolve. After drinking the mixture, rinse the glass with a small amount of beverage to make sure all the medication is taken. The granules can also be mixed with milk in breakfast cereals, or along with pulpy fruits such as crushed pineapple, pears, peaches, or fruit cocktail. The granules and orange granules should never be taken dry.

Other medications should be taken at least 1 hour before or 4 hours after Colestid (Colestipol).

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take Colestid (Colestipol) exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.