Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent. The side effects listed below are not experienced by everyone who takes Uromitexan (Mesna). If you are concerned about side effects, discuss the risks and benefits of Uromitexan (Mesna) with your doctor.

The following side effects have been reported by at least 1% of people taking Uromitexan (Mesna). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• abdominal pain
• Diarrhea
• flushing
• headache
• lightheadedness
• nausea
• redness or irritation at the infusion site
• skin rash
• unusually sleepy during the day

Although most of these side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• fast heart rate
• Fever
• flu-like symptoms (e.g., sore throat, fever, chills, shivering, cough, body aches)
• severe dizziness
• signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)

Stop taking the medication and seek immediate medical attention if any of the following occur:

• chest pain
• signs of a serious allergic reaction (i.e., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)
• signs of a severe skin reaction such as blistering, peeling, a rash covering a large area of the body, a rash that spreads quickly, or a rash combined with fever or discomfort

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Uromitexan (Mesna).

Preservative-free
Each mL of solution contains Uromitexan (Mesna) 100 mg. Nonmedicinal ingredients: disodium edetate, sodium hydroxide (for pH adjustments), and sterile water for injection.

Multi-dose vial
Each mL of solution contains 100 mg of Uromitexan (Mesna). Nonmedicinal ingredients: disodium edetate, sodium hydroxide, sterile water for injection, and benzyl alcohol (104 mg in the 10 mL vial; 520 mg in the 50 mL vial) as a preservative.

Uromitexan (Mesna) should not be used by anyone who is allergic to Uromitexan (Mesna) or to any of the ingredients of the medication.

Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. In many cases, interactions are intended or are managed by close monitoring. Speak to your doctor about how any drug interactions are being managed or should be managed.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Uromitexan (Mesna).

Drowsiness/reduced alertness: Uromitexan (Mesna) may cause drowsiness or dizziness, affecting your ability to drive or operate machinery. Avoid driving, operating machinery, or performing other potentially hazardous tasks until you have determined how Uromitexan (Mesna) affects you.

Tests for ketones in urine: Uromitexan (Mesna) may cause tests for ketones in the urine to be falsely positive.

Pregnancy: Uromitexan (Mesna) should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Uromitexan (Mesna), contact your doctor immediately. Because the use of oxazaphosphorines is not recommended during pregnancy, pregnant women should not need to take Uromitexan (Mesna).

Breast-feeding: It is not known if Uromitexan (Mesna) passes into breast milk. If you are a breast-feeding mother and are taking Uromitexan (Mesna), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.