The recommended adult dose of Constella (Linaclotide) to treat symptoms of irritable bowel syndrome with constipation is 290 µg taken once a day.

The recommended adult starting dose of Constella (Linaclotide) for chronic constipation is 145 µg taken once daily. Some people may be prescribed a dose of 72 µg taken once daily, depending on their response to the starting dose.

Constella (Linaclotide) should be taken on an empty stomach, at least 30 minutes before the first meal of the day. Do not crush or chew the capsules. Swallow the capsules whole with some water.

If you have trouble swallowing, the contents of the capsule may be sprinkled on applesauce or water. If you are using applesauce, sprinkle the contents of one capsule onto one teaspoon of applesauce and consume immediately. Do not chew the beads. Do not store for later use. If you are using water, open the capsule into a cup containing approximately 30 ml of bottled water. Gently swirl the beads and water for at least 20 seconds. Swallow the mixture. Add another 30 mL of water to the cup, swirl again for at least 20 seconds and swallow immediately. Do not store the bead and water mixture for later use. Note that this drug is coated on the surface of the beads, and the drug will dissolve into the water, but the beads will not dissolve. It is not necessary to consume all of the beads to get the full dose.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important that Constella (Linaclotide) be taken exactly as prescribed by your doctor.

If you miss a dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Constella (Linaclotide) at room temperature, in its original package. Protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.